[Extracorporeal lung support in patients with severe respiratory failure secondary to the 2010-2011 winter seasonal outbreak of influenza A (H1N1) in Spain].
Identifieur interne : 000288 ( Main/Exploration ); précédent : 000287; suivant : 000289[Extracorporeal lung support in patients with severe respiratory failure secondary to the 2010-2011 winter seasonal outbreak of influenza A (H1N1) in Spain].
Auteurs : J. Bonastre [Espagne] ; B. Suberviola ; J C Pozo ; J E Guerrero ; A. Torres ; A. Rodríguez ; I. Martín-LoechesSource :
- Medicina intensiva [ 1578-6749 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Antiviraux (usage thérapeutique), Atteinte rénale aigüe (thérapie), Atteinte rénale aigüe (étiologie), Choc septique (mortalité), Choc septique (étiologie), Durée du séjour (statistiques et données numériques), Défaillance multiviscérale (mortalité), Défaillance multiviscérale (étiologie), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (complications), Grippe humaine (traitement médicamenteux), Grippe humaine (épidémiologie), Humains (MeSH), Insuffisance respiratoire (thérapie), Insuffisance respiratoire (épidémiologie), Insuffisance respiratoire (étiologie), Mâle (MeSH), Oséltamivir (usage thérapeutique), Oxygénation extracorporelle sur oxygénateur à membrane (méthodes), Oxygénation extracorporelle sur oxygénateur à membrane (statistiques et données numériques), Pneumopathie virale (thérapie), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (épidémiologie), Pneumopathie virale (étiologie), Saisons (MeSH), Sous-type H1N1 du virus de la grippe A (isolement et purification), Syndrome de détresse respiratoire de l'adulte (thérapie), Syndrome de détresse respiratoire de l'adulte (épidémiologie), Syndrome de détresse respiratoire de l'adulte (étiologie), Traitement substitutif de l'insuffisance rénale (MeSH), Unités de soins intensifs (statistiques et données numériques), Ventilation artificielle (statistiques et données numériques), Épidémies de maladies (MeSH), Études prospectives (MeSH).
- MESH :
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- mortalité : Choc septique, Défaillance multiviscérale.
- méthodes : Oxygénation extracorporelle sur oxygénateur à membrane.
- statistiques et données numériques : Durée du séjour, Oxygénation extracorporelle sur oxygénateur à membrane, Unités de soins intensifs, Ventilation artificielle.
- thérapie : Atteinte rénale aigüe, Insuffisance respiratoire, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- traitement médicamenteux : Grippe humaine, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Grippe humaine, Oséltamivir.
- épidémiologie : Espagne, Grippe humaine, Insuffisance respiratoire, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- étiologie : Atteinte rénale aigüe, Choc septique, Défaillance multiviscérale, Insuffisance respiratoire, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- Adulte, Femelle, Humains, Mâle, Saisons, Traitement substitutif de l'insuffisance rénale, Épidémies de maladies, Études prospectives.
English descriptors
- KwdEn :
- Acute Kidney Injury (etiology), Acute Kidney Injury (therapy), Adult (MeSH), Antiviral Agents (therapeutic use), Disease Outbreaks (MeSH), Extracorporeal Membrane Oxygenation (methods), Extracorporeal Membrane Oxygenation (statistics & numerical data), Female (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (complications), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Intensive Care Units (statistics & numerical data), Length of Stay (statistics & numerical data), Male (MeSH), Multiple Organ Failure (etiology), Multiple Organ Failure (mortality), Oseltamivir (therapeutic use), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Pneumonia, Viral (etiology), Pneumonia, Viral (therapy), Prospective Studies (MeSH), Renal Replacement Therapy (MeSH), Respiration, Artificial (statistics & numerical data), Respiratory Distress Syndrome, Adult (epidemiology), Respiratory Distress Syndrome, Adult (etiology), Respiratory Distress Syndrome, Adult (therapy), Respiratory Insufficiency (epidemiology), Respiratory Insufficiency (etiology), Respiratory Insufficiency (therapy), Seasons (MeSH), Shock, Septic (etiology), Shock, Septic (mortality), Spain (epidemiology).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- complications : Influenza, Human.
- drug therapy : Influenza, Human, Pneumonia, Viral.
- epidemiology : Influenza, Human, Pneumonia, Viral, Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Spain.
- etiology : Acute Kidney Injury, Multiple Organ Failure, Pneumonia, Viral, Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Shock, Septic.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- methods : Extracorporeal Membrane Oxygenation.
- mortality : Multiple Organ Failure, Shock, Septic.
- statistics & numerical data : Extracorporeal Membrane Oxygenation, Intensive Care Units, Length of Stay, Respiration, Artificial.
- therapy : Acute Kidney Injury, Pneumonia, Viral, Respiratory Distress Syndrome, Adult, Respiratory Insufficiency.
- Adult, Disease Outbreaks, Female, Humans, Male, Prospective Studies, Renal Replacement Therapy, Seasons.
Abstract
OBJECTIVE
To describe the use of extracorporeal membrane oxygenation (ECMO) in refractory respiratory failure.
DESIGN
A prospective, observational, multi-center study was carried out.
SETTING
Intensive Care Units (ICU) in 148 Spanish hospitals.
PATIENTS
Subjects admitted during epidemic weeks 50-52 of 2010 and weeks 1-4 of 2011, receiving respiratory support with ECMO.
MAIN VARIABLES OF INTEREST
Clinical and blood gas features, complications and survival of patients with ECMO.
RESULTS
Out of 300 ICU admitted patients, 239 (79.6%) were mechanically ventilated. ECMO was available in only 5 ICUs. Nine patients were treated with ECMO (3% of the total and 3.2% of the ventilated patients). In 77.7% of the cases some hypoxemia rescue technique was previously used. ECMO was initiated when ARDS proved refractory to standard treatment. ECMO therapy was started a median of 4.5 days after the onset of mechanical ventilation. The median duration of ECMO was 6 days. Veno-venous (VV) ECMO was the most frequent cannulation mode (88.9%). Four patients had complications associated with ECMO therapy. The median ICU and hospital stay was 17 and 29 days, respectively. In five patients (55.5%), ECMO assistance was satisfactory suspended. The ICU and hospital survival rate was 44.4%.
CONCLUSIONS
The use of ECMO in refractory respiratory failure in patients with influenza A (H1N1) is rare in Spain. The hospital survival achieved with its use allows it to be regarded as a possible rescue technique in these patients.
DOI: 10.1016/j.medin.2011.12.004
PubMed: 22341559
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (etiology)</term>
<term>Acute Kidney Injury (therapy)</term>
<term>Adult (MeSH)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Disease Outbreaks (MeSH)</term>
<term>Extracorporeal Membrane Oxygenation (methods)</term>
<term>Extracorporeal Membrane Oxygenation (statistics & numerical data)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Intensive Care Units (statistics & numerical data)</term>
<term>Length of Stay (statistics & numerical data)</term>
<term>Male (MeSH)</term>
<term>Multiple Organ Failure (etiology)</term>
<term>Multiple Organ Failure (mortality)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (etiology)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Prospective Studies (MeSH)</term>
<term>Renal Replacement Therapy (MeSH)</term>
<term>Respiration, Artificial (statistics & numerical data)</term>
<term>Respiratory Distress Syndrome, Adult (epidemiology)</term>
<term>Respiratory Distress Syndrome, Adult (etiology)</term>
<term>Respiratory Distress Syndrome, Adult (therapy)</term>
<term>Respiratory Insufficiency (epidemiology)</term>
<term>Respiratory Insufficiency (etiology)</term>
<term>Respiratory Insufficiency (therapy)</term>
<term>Seasons (MeSH)</term>
<term>Shock, Septic (etiology)</term>
<term>Shock, Septic (mortality)</term>
<term>Spain (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Atteinte rénale aigüe (thérapie)</term>
<term>Atteinte rénale aigüe (étiologie)</term>
<term>Choc septique (mortalité)</term>
<term>Choc septique (étiologie)</term>
<term>Durée du séjour (statistiques et données numériques)</term>
<term>Défaillance multiviscérale (mortalité)</term>
<term>Défaillance multiviscérale (étiologie)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (complications)</term>
<term>Grippe humaine (traitement médicamenteux)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Insuffisance respiratoire (thérapie)</term>
<term>Insuffisance respiratoire (épidémiologie)</term>
<term>Insuffisance respiratoire (étiologie)</term>
<term>Mâle (MeSH)</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Oxygénation extracorporelle sur oxygénateur à membrane (méthodes)</term>
<term>Oxygénation extracorporelle sur oxygénateur à membrane (statistiques et données numériques)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Pneumopathie virale (étiologie)</term>
<term>Saisons (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Syndrome de détresse respiratoire de l'adulte (thérapie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (épidémiologie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (étiologie)</term>
<term>Traitement substitutif de l'insuffisance rénale (MeSH)</term>
<term>Unités de soins intensifs (statistiques et données numériques)</term>
<term>Ventilation artificielle (statistiques et données numériques)</term>
<term>Épidémies de maladies (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Respiratory Insufficiency</term>
<term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Acute Kidney Injury</term>
<term>Multiple Organ Failure</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Respiratory Insufficiency</term>
<term>Shock, Septic</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Extracorporeal Membrane Oxygenation</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Multiple Organ Failure</term>
<term>Shock, Septic</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Choc septique</term>
<term>Défaillance multiviscérale</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Oxygénation extracorporelle sur oxygénateur à membrane</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Extracorporeal Membrane Oxygenation</term>
<term>Intensive Care Units</term>
<term>Length of Stay</term>
<term>Respiration, Artificial</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Durée du séjour</term>
<term>Oxygénation extracorporelle sur oxygénateur à membrane</term>
<term>Unités de soins intensifs</term>
<term>Ventilation artificielle</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Acute Kidney Injury</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Distress Syndrome, Adult</term>
<term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Atteinte rénale aigüe</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Grippe humaine</term>
<term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
<term>Grippe humaine</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Atteinte rénale aigüe</term>
<term>Choc septique</term>
<term>Défaillance multiviscérale</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Prospective Studies</term>
<term>Renal Replacement Therapy</term>
<term>Seasons</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Saisons</term>
<term>Traitement substitutif de l'insuffisance rénale</term>
<term>Épidémies de maladies</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To describe the use of extracorporeal membrane oxygenation (ECMO) in refractory respiratory failure.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>DESIGN</b>
</p>
<p>A prospective, observational, multi-center study was carried out.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>SETTING</b>
</p>
<p>Intensive Care Units (ICU) in 148 Spanish hospitals.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>PATIENTS</b>
</p>
<p>Subjects admitted during epidemic weeks 50-52 of 2010 and weeks 1-4 of 2011, receiving respiratory support with ECMO.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MAIN VARIABLES OF INTEREST</b>
</p>
<p>Clinical and blood gas features, complications and survival of patients with ECMO.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Out of 300 ICU admitted patients, 239 (79.6%) were mechanically ventilated. ECMO was available in only 5 ICUs. Nine patients were treated with ECMO (3% of the total and 3.2% of the ventilated patients). In 77.7% of the cases some hypoxemia rescue technique was previously used. ECMO was initiated when ARDS proved refractory to standard treatment. ECMO therapy was started a median of 4.5 days after the onset of mechanical ventilation. The median duration of ECMO was 6 days. Veno-venous (VV) ECMO was the most frequent cannulation mode (88.9%). Four patients had complications associated with ECMO therapy. The median ICU and hospital stay was 17 and 29 days, respectively. In five patients (55.5%), ECMO assistance was satisfactory suspended. The ICU and hospital survival rate was 44.4%.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>The use of ECMO in refractory respiratory failure in patients with influenza A (H1N1) is rare in Spain. The hospital survival achieved with its use allows it to be regarded as a possible rescue technique in these patients.</p>
</div>
</front>
</TEI>
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<Month>09</Month>
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<Issue>3</Issue>
<PubDate><Year>2012</Year>
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<Title>Medicina intensiva</Title>
<ISOAbbreviation>Med Intensiva</ISOAbbreviation>
</Journal>
<ArticleTitle>[Extracorporeal lung support in patients with severe respiratory failure secondary to the 2010-2011 winter seasonal outbreak of influenza A (H1N1) in Spain].</ArticleTitle>
<Pagination><MedlinePgn>193-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.medin.2011.12.004</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To describe the use of extracorporeal membrane oxygenation (ECMO) in refractory respiratory failure.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">A prospective, observational, multi-center study was carried out.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">Intensive Care Units (ICU) in 148 Spanish hospitals.</AbstractText>
<AbstractText Label="PATIENTS" NlmCategory="METHODS">Subjects admitted during epidemic weeks 50-52 of 2010 and weeks 1-4 of 2011, receiving respiratory support with ECMO.</AbstractText>
<AbstractText Label="MAIN VARIABLES OF INTEREST" NlmCategory="METHODS">Clinical and blood gas features, complications and survival of patients with ECMO.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Out of 300 ICU admitted patients, 239 (79.6%) were mechanically ventilated. ECMO was available in only 5 ICUs. Nine patients were treated with ECMO (3% of the total and 3.2% of the ventilated patients). In 77.7% of the cases some hypoxemia rescue technique was previously used. ECMO was initiated when ARDS proved refractory to standard treatment. ECMO therapy was started a median of 4.5 days after the onset of mechanical ventilation. The median duration of ECMO was 6 days. Veno-venous (VV) ECMO was the most frequent cannulation mode (88.9%). Four patients had complications associated with ECMO therapy. The median ICU and hospital stay was 17 and 29 days, respectively. In five patients (55.5%), ECMO assistance was satisfactory suspended. The ICU and hospital survival rate was 44.4%.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The use of ECMO in refractory respiratory failure in patients with influenza A (H1N1) is rare in Spain. The hospital survival achieved with its use allows it to be regarded as a possible rescue technique in these patients.</AbstractText>
<CopyrightInformation>Copyright © 2011 Elsevier España, S.L. and SEMICYUC. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bonastre</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Servicio Medicina Intensiva, Hospital Universitario y Politécnico La Fe, CIBER Enfermedades Respiratorias, Valencia, España. jbonastremora@gmail.com</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suberviola</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pozo</LastName>
<ForeName>J C</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Guerrero</LastName>
<ForeName>J E</ForeName>
<Initials>JE</Initials>
</Author>
<Author ValidYN="Y"><LastName>Torres</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rodríguez</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Martín-Loeches</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>SEMICYUC-CIBERES-REIPI working group</CollectiveName>
</Author>
</AuthorList>
<Language>spa</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<VernacularTitle>Uso de oxigenador de membrana extracorpóreo en pacientes con insuficiencia respiratoria aguda grave refractaria en la epidemia de gripe estacional 2010-2011 por influenza A (H1N1) en España.</VernacularTitle>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>02</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Spain</Country>
<MedlineTA>Med Intensiva</MedlineTA>
<NlmUniqueID>9207689</NlmUniqueID>
<ISSNLinking>0210-5691</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>20O93L6F9H</RegistryNumber>
<NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D058186" MajorTopicYN="N">Acute Kidney Injury</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015199" MajorTopicYN="N">Extracorporeal Membrane Oxygenation</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009102" MajorTopicYN="N">Multiple Organ Failure</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017582" MajorTopicYN="N">Renal Replacement Therapy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012772" MajorTopicYN="N">Shock, Septic</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year>
<Month>10</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2011</Year>
<Month>11</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>12</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>2</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>2</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>9</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22341559</ArticleId>
<ArticleId IdType="pii">S0210-5691(12)00008-3</ArticleId>
<ArticleId IdType="doi">10.1016/j.medin.2011.12.004</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
</list>
<tree><noCountry><name sortKey="Guerrero, J E" sort="Guerrero, J E" uniqKey="Guerrero J" first="J E" last="Guerrero">J E Guerrero</name>
<name sortKey="Martin Loeches, I" sort="Martin Loeches, I" uniqKey="Martin Loeches I" first="I" last="Martín-Loeches">I. Martín-Loeches</name>
<name sortKey="Pozo, J C" sort="Pozo, J C" uniqKey="Pozo J" first="J C" last="Pozo">J C Pozo</name>
<name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A" last="Rodríguez">A. Rodríguez</name>
<name sortKey="Suberviola, B" sort="Suberviola, B" uniqKey="Suberviola B" first="B" last="Suberviola">B. Suberviola</name>
<name sortKey="Torres, A" sort="Torres, A" uniqKey="Torres A" first="A" last="Torres">A. Torres</name>
</noCountry>
<country name="Espagne"><noRegion><name sortKey="Bonastre, J" sort="Bonastre, J" uniqKey="Bonastre J" first="J" last="Bonastre">J. Bonastre</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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